Juan Carlos Mobarec

Structural basis of biofilm formation mediated by the Pseudomonas aeruginosa fibrillar adhesin CdrA

This study determines the structure of CdrA, a fibrillar adhesin in Pseudomonas aeruginosa, revealing its role in biofilm formation and identifying targets for inhibition.

Clinical Trial and Ontology-Derived Positive and Negative Benchmark Datasets for Drug Repurposing Across Rare Diseases

The paper introduces two benchmark datasets for drug repurposing across rare diseases: a positive dataset from clinical trials and a negative dataset from disease ontologies, enabling evaluation of computational models for disease-drug associations.

A metagenomic thermostable monomeric meganuclease with novel specificity and unique palindromic 3-prime overhangs

The paper discovers a novel thermostable monomeric meganuclease from metagenomic data with unique DNA recognition and cleavage properties.

Topology-Driven Negative Sampling Enhances Generalizability in Protein-Protein Interaction Prediction

This paper introduces a method to improve protein-protein interaction prediction by using topology-driven negative sampling and an ML pipeline that enhances generalizability and interpretability.

Representation Learning of Human Diseases for Indication Expansion and Investment Decisions

This paper introduces Dis2Vec, a representation learning framework for human diseases that enables therapeutic transferability prediction and disease clustering, enhancing translational research efficiency.

Robust prediction of relative binding energies for protein-protein complex mutations using free energy perturbation calculations

The paper benchmarks free energy perturbation calculations for predicting mutation effects on protein-protein binding affinity and introduces an automated method to improve accuracy.