Samuel J. Barnes

The paper identifies stage-specific synaptic proteomic signatures in Alzheimer's disease and links them to plasma proteins associated with disease progression and cognitive decline.

The paper develops a spatial averaging framework to analyze glial subcellular specialization in spatial transcriptomics data from mouse and human brain tissue, revealing differential transcriptomic responses between glial soma and processes in health and disease.

This paper introduces a deep learning method to improve calcium imaging by reducing scattering and increasing throughput in light-field microscopy.

The paper shows TSPO expression increases in activated microglia in rodent models but not in human neurodegenerative diseases, indicating species-specific differences in TSPO function.

The paper shows that homeostatic regulation in neurons involves strengthening network-correlated synaptic inputs rather than sensory inputs during sensory deprivation.

The paper uses computational modeling to show that network size determines diverse homeostatic responses to visual deprivation in mouse visual cortex, with larger networks showing stronger recovery.