Sebastian Werneburg

A conserved molecular marker for connections between two evolutionarily distinct visual centers

The paper identifies a conserved molecular marker in the dLGN that correlates with SC connections in mice and tree shrews, and confirms its presence in humans.

Integrated stress response associated with dark microglia promotes microglial lipogenesis and contributes to neurodegeneration

The paper identifies a neurodegenerative microglia phenotype driven by the integrated stress response (ISR) and shows that inhibiting ISR ameliorates neurodegenerative pathologies in AD models.

IRF3 regulates neuroinflammatory responses and the expression of genes associated with Alzheimer's disease.

This study shows IRF3 regulates neuroinflammatory responses and Alzheimer's disease-related gene expression through its effects on microglia and myeloid cells.

Non-Coding Genetic Analysis Implicates Interleukin 18 Receptor Accessory Protein 3'UTR in Amyotrophic Lateral Sclerosis

The paper identifies non-coding variants in the IL18RAP 3'UTR that reduce ALS risk by modulating neuro-inflammation through NF-κB signaling in microglia.

Targeted complement inhibition at synapses prevents microglial synaptic engulfment and synapse loss in demyelinating disease

This study identifies synapse loss and microglial synaptic engulfment in MS models and demonstrates that targeted complement inhibition prevents synapse loss and visual dysfunction.