James A. Scarth

The HPV E7 oncoprotein promotes LIM and SH3 Domain Protein 1 (LASP1) transcription via the Rb/E2F1 signalling pathway in HPV-positive cervical cancer cells

This study shows HPV E7 promotes LASP1 transcription through the Rb/E2F1 pathway in cervical cancer cells, adding to previously identified miR-203 regulation.

High levels of DNA replication initiation factors indicate ATR inhibitor sensitivity via excessive origin firing

This study identifies that high levels of DNA replication initiation factors correlate with ATR inhibitor sensitivity due to excessive origin firing in cancer cells.

YAP engages RIF1 to dampen replication stress-induced DNA damage in human squamous cell carcinoma.

This study identifies YAP's interaction with RIF1 in squamous cell carcinoma, showing it reduces replication stress-induced DNA damage through non-transcriptional mechanisms.