STAG2 cohesin cooperates with DREAM to maintain quiescence and suppress tumourigenesis in the urothelium
Maria Ramal, Eleonora Lapi, Mark Kalisz, Jaime Martínez de Villarreal, Meritxell Novillo-Font, Miriam Marqués, Eduardo Zarzuela, Marta Isasa, Osvaldo Graña‐Castro, Jianming Xu, Ana Cayuela López, François Radvanyi, Mireia Novell, Jorge Luis Martinez-Torrecuadrada, Marı́a José Barallobre, , Francisco X. Real
This study shows that STAG2 cohesin works with DREAM to maintain quiescence and prevent tumor formation in urothelial cells by regulating chromatin structure and cell cycle control.
bioRxiv · Oct 10, 2025 · PreprintCancer Biology