Marta Isasa

This study reveals the HSP90-CDC37 chaperone system's role in RAF1 activation through pre-dimerization and asymmetric folding, showing its active regulatory role in MEK signaling and cell proliferation.

This study identifies CCDC6-RET as a dual ATP/ADP-dependent kinase with a unique dimeric structure and phosphorylation mechanism, revealing structural and functional determinants of its oncogenic activity.

This study shows that CCNY overexpression causes a fatal metabolic syndrome by disrupting glucose homeostasis and inducing a Warburg-like metabolic shift.

This study shows CDC14 phosphatases regulate adipogenesis by dephosphorylating PPARγ, improving glucose metabolism and preventing obesity in mice.

This study shows that STAG2 cohesin works with DREAM to maintain quiescence and prevent tumor formation in urothelial cells by regulating chromatin structure and cell cycle control.

This study identifies GNF-7 as a senolytic drug that activates GCN2 to kill senescent cells, showing synergy with CDK4/6 inhibitors in preclinical models.