Masato Koike

Paw switching with lateralized cholinergic modulation

This study shows that cholinergic modulation between brain hemispheres enables paw preference switching in mice through experience-driven changes in neural activity.

The difference in immunohistochemical reactivity of monoclonal antibodies against amino-terminal residues of amyloid-β peptide

The paper evaluates the immunohistochemical reactivity of three anti-Aβ antibodies in AD mouse models, finding significant differences in staining patterns and suggesting antibody-specific effects beyond sensitivity.

A Three Dimensional Immunolabeling Method with Peroxidase-fused Nanobodies and Fluorochromized Tyramide-Glucose Oxidase Signal Amplification

This paper introduces a 3D immunolabeling method for high-speed and high-sensitive detection of targets in 3D tissues, demonstrating its application in visualizing neuronal and glial cells in mouse brain tissues.

Loss of SPNS1, a lysosomal transporter, in the nervous system causes dysmyelination and white matter dysplasia

This study shows that loss of SPNS1 in the nervous system causes dysmyelination and white matter dysplasia in mice, suggesting a role for SPNS1 mutations in human congenital white matter disorders.

Plaque-associated endogenous IgG and its impact on immunohistochemical detection of mouse monoclonal IgG antibodies in mouse models of Alzheimer's disease

The paper identifies plaque-associated endogenous IgG in AD mouse models that interferes with immunohistochemical detection of mouse monoclonal IgG antibodies and shows that subclass-specific secondary antibodies can mitigate this issue.

FT-GO: a multiplex fluorescent tyramide signal amplification system for histochemical analysis

FT-GO improves fluorescent histochemical analysis by enhancing signal detection while reducing background noise in mouse and marmoset brains.

Multi-Scale LM/EM Neuronal Imaging from Brain to Synapse with a Tissue Clearing Method, ScaleSF

This paper develops a multi-scale neuronal imaging technique combining light and electron microscopy with a tissue clearing method to study brain-wide connectivity across multiple spatial scales.