Author

Jennifer M. Spangle

Emory UniversityORCID 0000-0002-0181-3244Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:yeast· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Anita H. CorbettiD· 2 shared Milo B. FaskeniD· 2 shared Alexander O. D. GulkaiD· 1 shared Alexia Tyler King· 1 shared Alicia R. LaneiD· 1 shared Anna J. VossiD· 1 shared Anson David SingiD· 1 shared Aparna BhaduriiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersGenetics

Anita H. CorbettORCID

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3 papers

Recent·Most cited

Overexpression of Eaf1, a subunit of the NuA4 lysine acetyltransferase complex, rescues growth defects in the budding yeast H3K36M oncohistone model via histone H4 tail acetylation

Celina Y. Jones, L Chen, Milo B. Fasken, Anita H. Corbett, Jennifer M. Spangle

This paper shows that overexpressing Eaf1, a NuA4 subunit, rescues growth defects in yeast with H3K36M mutations by acetylating histone H4 tails.

bioRxiv · Jun 26, 2026 · PreprintGenetics

Lead (Pb) exposure alters neural cell fate in the developing human brain

Maureen McGuirk Sampson, Sayli Sonsurkar, Lisa Nieland, Lin Pan, Ryan L. Kan, Daria J. Azizad, Xiang Li, Nardos Kebede, Alicia R. Lane, Priya E D'Souza, Parinya Panuwet, Emily J. Hill, Samantha N. Lanjewar, Anna J. Voss, Dorelle V. Fawwal, , Steven A. Sloan

This study shows that prenatal lead exposure biases neural cell fate in human brain development by increasing neurons and reducing astrocytes through epigenetic changes.

bioRxiv · Aug 14, 2025 · PreprintNeuroscience

A Budding Yeast Model and Screen to Define the Functional Consequences of Oncogenic Histone Missense Mutations

Laramie D. Lemon, Sneha Kannan, Kim Wai Mo, Miranda Adams, Haley G. Choi, Alexander O. D. Gulka, Elise S. Withers, Hasset T. Nurelegne, Valeria Gomez, Reina E. Ambrocio, Rhea Tumminkatti, Richard Sean Lee, Morris Wan, Milo B. Fasken, Jennifer M. Spangle, Anita H. Corbett

The paper uses a budding yeast model to study the functional effects of oncogenic histone missense mutations and identifies suppressor genes involved in histone function and transcriptional regulation.

G3 Genes Genomes Genetics · May 14, 2022Peer-reviewedGenetics