Chiara Azzi

Protein degradation shapes developmental tempo in mouse and human neural progenitors

The paper compares protein dynamics in mouse and human neural progenitors, finding that human NPs have longer protein half-lives and lower proteasomal activity, which influences developmental tempo.

Convergence of multiple RNA-silencing pathways on GW182/TNRC6

The paper identifies TRIM71's mechanism of mRNA silencing through recruitment of TNRC6/GW182 and shows competition among silencing pathways.

The Grainyhead/LSF transcription factor GRH-1 is rhythmically required for molting

The paper identifies GRH-1 as a transcription factor essential for rhythmic molting in C. elegans, showing its role in gene regulation and cuticle formation.

Two parallel arms of the heterochronic pathway direct coordinated juvenile-to-adult transition through distinct LIN-29 isoforms

The paper identifies two LIN-29 isoforms that regulate distinct aspects of the juvenile-to-adult transition in C. elegans through differential spatiotemporal expression and regulatory control by LIN-28, LIN-41, and HBL-1.