Ralf Kittler

Pharmacologic inhibition of OLIG2 by CT-179 disrupts mitotic progression and enhances standard-of-care chemoradiotherapy in glioblastoma

This study shows that CT-179, an OLIG2 inhibitor, reduces glioblastoma growth and enhances chemoradiotherapy efficacy in preclinical models.

A microbiota-derived bile acid overcomes antibiotic-induced hyporesponsiveness to immune checkpoint therapy by enhancing CD8+ T cell antitumor immunity

This study identifies TDCA, a microbiota-derived bile acid, as a mediator that restores immune checkpoint therapy efficacy after antibiotic-induced hyporesponsiveness by enhancing CD8+ T cell antitumor immunity.

Phenotypic and Functional Characterization of Oncohistone Mutations in Breast Cancers

This study identifies and characterizes 17 high frequency oncohistone mutations in breast cancer that promote cancer-related phenotypes and may act as potential cancer drivers.

Dual inhibition of ATR and DNA-PKcs radiosensitizes ATM-mutant prostate cancer

This study shows that dual inhibition of ATR and DNA-PKcs radiosensitizes ATM-deficient prostate cancer cells, with Compound B effectively achieving this in vitro and in vivo.

GCNA preserves genome integrity and fertility across species

The paper identifies GCNA as a conserved regulator of genome stability in germ cells across species, showing its role in preventing DNA damage and maintaining fertility.