Lori L. O’Brien

Feature-Driven Whole-Tissue Imaging with Subcellular Resolution

The paper introduces MCT-ASLM, a microscopy platform that enables subcellular resolution imaging of whole tissues, demonstrating its application in studying neuronal circuits, kidney innervation, and tumor microenvironments.

Somites are a source of nephron progenitors in zebrafish

The paper shows that some nephrons in zebrafish kidneys originate from somites, challenging the belief that kidneys only come from intermediate mesoderm.

Altered renal vascular patterning reduces ischemic kidney injury and limits vascular loss associated with aging

This study shows that altered renal vascular patterning reduces ischemic kidney injury and preserves vascular function in aging mice.

Comprehensive mapping of sensory and sympathetic innervation of the developing kidney

This study maps the development of sensory and sympathetic innervation in the kidney, identifying key nerve types and their origins.

The tricellular junctional protein Ildr2 helps maintain glomerular podocyte architecture

This study investigates the role of Ildr2 in maintaining podocyte architecture and finds that its deletion causes structural changes in podocytes but not significant albuminuria under normal conditions.

Netrin-1 directs vascular patterning and maturity in the developing kidney

This study shows that Netrin-1 from stromal progenitors in the developing kidney is essential for vascular patterning and maturity, as its deletion leads to hypoplastic kidneys with altered vascular features.

Mapping of the podocin proximity-dependent proteome reveals novel components of the kidney podocyte foot process

The paper uses BioID to identify proteins localized to the podocyte slit diaphragm, discovering novel components and age-related changes in the foot process proteome.

Content and performance of the MiniMUGA genotyping array, a new tool to improve rigor and reproducibility in mouse research

The paper introduces MiniMUGA, a genotyping array for mouse genetic QC, showing it effectively discriminates strains, detects genetic constructs, and identifies sex chromosome abnormalities.