Francesca W. van Tartwijk

Antarctic fish cell cultures show adaptation of organelle morphology and dynamics to extreme cold

The paper studies subcellular organization and dynamics in Antarctic fish cell cultures, finding conserved organelle structures but differences in lysosomal size and mitochondrial morphology that may relate to cold adaptation.

SIMple: A fibre-based platform for accessible structured illumination microscopy

The paper introduces a fibre-based structured illumination microscopy (SIM) system that simplifies setup and improves resolution without specialized optics.

An Enhanced Mountain Climbing Search Algorithm to Enable Fast and Accurate Autofocusing in High Resolution Fluorescence Microscopy

This paper introduces an enhanced mountain climbing search algorithm for fast and accurate autofocus in high-resolution fluorescence microscopy, achieving up to 200-fold improvement in precision over existing methods.

A high-resolution microscopy system for biological studies of cold-adapted species under physiological conditions

This paper develops a high-resolution microscopy method for imaging live biological samples at sub-zero temperatures to study cold-adapted species under physiological conditions.

Mutation of the ALS/FTD-associated RNA-binding protein FUS alters axonal cytoskeletal organisation

The paper investigates how mutations in the FUS protein affect axonal cytoskeletal organisation in ALS/FTD models, finding reduced actin density and axonal branch complexity.

A waveguide imaging platform for live-cell TIRF imaging of neurons over large fields of view

This paper introduces a waveguide-based TIRFM system for live-cell imaging of delicate neurons over large fields of view, demonstrating its use with fibroblasts, rat hippocampal neurons, and Xenopus retinal ganglion cells.

On-site ribosome remodeling by locally synthesized ribosomal proteins in axons

The paper shows that ribosomal proteins are synthesized locally in axons and incorporated into ribosomes in a nucleolus-independent manner, regulated by a novel RNA motif.