Robert A. Weinberg

Ether lipids influence cancer cell fate by modulating iron uptake

This study shows that ether lipids in cancer cells regulate membrane properties to influence iron uptake, ferroptosis, and metastasis, offering a therapeutic target.

Primary cilia promote EMT-induced triple-negative breast tumor heterogeneity and resistance to therapy

This study shows primary cilia in TNBC cells contribute to chemoresistance by supporting EMT-driven heterogeneity and stemness, and inhibiting ciliogenesis reduces this resistance.

CD47 predominates over CD24 as a macrophage immune checkpoint in cancer.

This study identifies CD47 as a more effective macrophage immune checkpoint than CD24 in cancer and develops bispecific antibodies to enhance macrophage-mediated tumor killing.