Scott Keeney

The paper identifies YTHDC2 as essential for meiotic progression in mice, showing its role in gene expression transitions and its evolutionary conservation.

The paper introduces S1-seq, a next-generation sequencing assay to study DNA end resection during yeast meiosis, and describes its experimental and computational methods.

This study shows that the mouse SWS1-SWSAP1 complex is essential for meiotic recombination by promoting RAD51 and DMC1 focus formation, with BRCA2 C terminus playing a modulatory role.

The paper identifies Mek1 as the kinase responsible for H3 T11 phosphorylation in meiosis and shows H3 T11ph serves as a marker of Mek1 activity.

The paper identifies Dnmt3c as a fifth DNA methyltransferase paralog essential for retrotransposon methylation and male germline function in mice, revealing its role in meiosis and transposon repression.

This study investigates the genomic and chromatin features influencing meiotic DSB formation and repair in mice, identifying roles for PRDM9 and ATM in hotspot activity and recombination outcomes.

This paper identifies distinct DNA-binding surfaces in MutLγ that mediate different functions in meiotic recombination and mismatch repair, revealing separable roles for Mlh1 and Mlh3.

This study investigates Tel1's role in regulating meiotic DNA breaks in yeast by analyzing Spo11-oligonucleotide complexes and their distribution.

The paper maps meiotic resection endpoints genome-wide in yeast, revealing heterogeneity and the role of Exo1 and Tel1 in resection initiation and processivity.

The paper compares meiotic recombination initiation maps across yeast species to test whether hotspot positions and strengths are conserved or ephemeral.

This study examines sex-specific differences in meiotic recombination outcomes at two mouse hotspots, finding sex-specific biases in crossover formation and showing DSB frequency is not the sole determinant of crossover frequency.