James H. Thierer

A whole-animal phenotypic drug screen identifies suppressors of atherogenic lipoproteins

A zebrafish phenotypic drug screen identifies 49 ApoB-lowering compounds, with enoxolone showing efficacy dependent on HNF4 function, validating the LipoGlo platform for B-lp modulation.

Fluorescently-labeled split-QF hemidrivers: simplifying and enhancing methods enabling intersectional targeting of discrete cell types

The paper develops fluorescently labeled split-QF and QF2 hemidrivers in zebrafish to simplify intersectional targeting and enable quality control of split-driver function.

Mesenchymal-derived neural progenitors underlie local insulin production and neuronal transdifferentiation during retina regeneration

This study identifies mesenchymal-derived neural progenitors that transdifferentiate into retinal ganglion cells in zebrafish after neuronal ablation, revealing a novel mechanism for retinal regeneration.

Molecular regulation of retinal regeneration is context specific

The paper identifies 18 genes regulating retinal ganglion cell regeneration in zebrafish using a combination of genetic models and single-cell omics.

LipoGlo: A sensitive and specific reporter of atherogenic lipoproteins

The paper introduces LipoGlo, a system using ApoB-fused luciferase to monitor lipoprotein atherogenicity in zebrafish, revealing new localization patterns and identifying a regulator of lipoprotein size.