Author

Liyun Zhang

Johns Hopkins UniversityORCID 0000-0002-0814-4872Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:zebrafish· 4 Research Focus:drug response / drug discovery· 3 Research Focus:differential expression· 1 Organism:mouse· 1 Assay:proteomics· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Jeff S. MummiD· 4 shared Abigail V. SharrockiD· 2 shared David F. AckerleyiD· 2 shared James H. ThiereriD· 2 shared Jiang X. QianiD· 2 shared Jun O. LiuiD· 2 shared Kevin EmmerichiD· 2 shared Meera T. SaxenaiD· 2 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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4 shared papersNeuroscience

Jeff S. MummORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A whole-animal phenotypic drug screen identifies suppressors of atherogenic lipoproteins

Daniel J. Kelpsch, Liyun Zhang, James H. Thierer, Adrian G. Rivera Cruz, Kobe Koren, Urmi Kumar, Yuki Lin, Monica R. Hensley, Mira Sohn, Jun O. Liu, Thomas Lectka, Jeff S. Mumm, Steven Arthur Farber

A zebrafish phenotypic drug screen identifies 49 ApoB-lowering compounds, with enoxolone showing efficacy dependent on HNF4 function, validating the LipoGlo platform for B-lp modulation.

eLife · Aug 27, 2026Peer-reviewedPhysiology

Molecular regulation of retinal regeneration is context specific

Kevin Emmerich, John Hageter, Thanh V. Hoang, Pin Lyu, Abigail V. Sharrock, Anneliese Ceisel, James H. Thierer, Zeeshaan Chunawala, Saumya Nimmagadda, Isabella Palazzo, Frazer Matthews, Liyun Zhang, David T. White, Catalina Rodriquez, Gianna Graziano, , Jeff S. Mumm

The paper identifies 18 genes regulating retinal ganglion cell regeneration in zebrafish using a combination of genetic models and single-cell omics.

bioRxiv · Nov 20, 2023 · PreprintNeuroscience

Large-scale Phenotypic Drug Screen Identifies Neuroprotectants in Zebrafish and Mouse Models of Retinitis Pigmentosa

Liyun Zhang, Conan Y. Chen, Jie Fu, Brendan N. Lilley, Cynthia A. Berlinicke, Baranda S. Hansen, Ding Ding, Guohua Wang, Tao Wang, Daniel Shou, Ying Ye, Timothy S. Mulligan, Kevin Emmerich, Meera T. Saxena, Kelsi R. Hall, , Jeff S. Mumm

The paper identifies neuroprotective compounds for retinitis pigmentosa using cross-species drug screens in zebrafish and mouse models, finding additive effects in some combinations.

eLife · Jun 29, 2021Peer-reviewedNeuroscience

Drug Screening with Zebrafish Visual Behavior Identifies Carvedilol as a Potential Treatment for Retinitis Pigmentosa

Logan C. Ganzen, Mee Jung Ko, Mengrui Zhang, Rui Xie, Yongkai Chen, Liyun Zhang, Rebecca James, Jeff S. Mumm, Richard M. van Rijn, Wenxuan Zhong, Chi Pui Pang, Mingzhi Zhang, Motokazu Tsujikawa, Yuk Fai Leung

This study screens drugs using zebrafish visual behavior to identify carvedilol as a potential treatment for retinitis pigmentosa.

Scientific Reports · Jun 1, 2021Peer-reviewedNeuroscience