Simonetta Gribaldo

Archaeal cell envelopes selectively activate innate immunity through TLR2 in contrasts with multi-receptor bacterial sensing

This study shows that archaeal cell envelopes activate innate immunity via TLR2, unlike bacteria which use multiple PRRs.

Arm and head domain in highly conserved lipoprotein modification enzyme Lgt determine functional diversity among bacterial pathogens

The paper analyzes Lgt homologues across bacterial pathogens to determine functional diversity and catalytic mechanisms, identifying a conserved motif and substrate specificity differences.

Biogenesis of DNA-carrying extracellular vesicles by the dominant human gut methanogenic archaeon

This study characterizes DNA-carrying extracellular vesicles (EVs) from Methanobrevibacter smithii, revealing their role in DNA and protein export in the gut.

Functional and phylogenomic approaches reveal novel types of M42 peptidases with contrasted enzymatic properties in Archaea

The paper identifies and classifies novel M42 peptidases in Archaea, revealing their functional diversity and evolutionary history through phylogenomic and structural analyses.

Horizontal gene transfer of the functional archaellum machinery to Bacteria

The paper shows that archaellum gene clusters, which enable motility, are present in bacteria and originated from horizontal gene transfer from archaea.

Identification of V. parvula and S. gordonii adhesins mediating co-aggregation and its impact on physiology and mixed biofilm structure

This study identifies adhesins in V. parvula and S. gordonii that mediate co-aggregation and shows its role in biofilm structure without affecting cell-cell communication.

Sporadic distribution of a new archaeal genetic code with all TAG codons as pyrrolysine

The paper confirms a new archaeal genetic code (Code 34) where TAG codons encode pyrrolysine, showing sporadic distribution and lateral gene transfer.

Resolving phylogenetic and biochemical barriers to functional expression of heterologous iron-sulphur cluster enzymes

The paper investigates why iron-sulphur cluster enzymes are often inactive when heterologously expressed in E. coli and identifies strategies to improve their functionality.

A comprehensive analysis of the global human gut archaeome from a thousand genome catalogue

The paper analyzes 1,167 archaeal genomes from the human gut to reveal novel species, genomic adaptations, and correlations with socio-demographic factors.