Hong Qian

A modular lentiviral system for multiplexed gene perturbation and functional analysis suggests interdependence of hormone receptors in breast cancer growth in vivo

The paper introduces a modular lentiviral system for multiplexed gene perturbation and functional analysis, showing that ER+ breast cancer cells rely on AR, ER, and PR for in vivo growth.

Human growth plates house resting zone sub-populations with features of quiescent stem cells

This study characterizes gene expression in human growth plates, identifying novel markers and sub-populations of resting zone chondrocytes with features of quiescent stem cells.

Megakaryocytes assemble a three-dimensional cage of extracellular matrix that controls their maturation and anchoring to the vascular niche

This paper identifies a three-dimensional extracellular matrix cage formed by laminin and collagen IV that anchors megakaryocytes in the bone marrow and regulates their maturation and intravasation.