The paper identifies a female-specific microglial redox program that influences susceptibility to obesity by modulating metabolic resilience and mTORC1 signaling.

bioRxiv · Sep 9, 2026 · PreprintNeuroscience

Single-Nuclei Analysis of the Unfolded Protein Response (SNUPR): A Novel Method revealing bortezomib resistance mechanisms in Multiple Myeloma

Julien Paul Gigan, Paulina A García-González, Angelo Pilotti, Lou Galliot, A Reynaud, Yoan Ghaffar, Felipe Flores‐Santibáñez, Sara Ghafoori, Eve Seillier, Rosario Lavignolle, Daniela Barros, Caroline Bret, Sharon Fichaux, Alexis J. Combes, Alessandro Bani, , Rafael José Argüello

SNUPR enables single-cell UPR profiling and reveals the role of IRE-1 axis in predicting bortezomib resistance in multiple myeloma.

EMBO Molecular Medicine · Jun 29, 2026Peer-reviewedCancer Biology

Plasmacytoid dendritic cells are dispensable or detrimental in murine systemic or respiratory viral infections

Clemence Ngo, Camille Pierini-Malosse, Khalissa Rahmani, Michael Valente, Nils Collinet, Gilles Bessou, Capucine Guerry, Manon Fabregue, Solene Mathieu, Sarah Sharkaoui, Sophie Mazzoli, Amandine Sansoni, Frédéric FIORE, Caroline Laprie, Lena Alexopoulou, , Elena Tomasello

This study shows that plasmacytoid dendritic cells (pDCs) and their interferons are dispensable or harmful in systemic and respiratory viral infections in mice.

Nature Immunology · Sep 29, 2025Peer-reviewedImmunology

Heparan sulfate glycosaminoglycans mediate CXCL4 (PF4) transport across the blood-brain barrier and effects on neurogenesis

Riley R. Weaver, Anna L. Gray, Saudina Mateus-Gomes, Amanda J. L. Ridley, Sean Patrick Giblin, Holly L. Birchenough, Francis C. Peterson, K. Lowe, Yui Matsubara, Iashia Z. Mulholland, Ingo Schießl, Thomas A. Jowitt, James Edward Pease, William A. Banks, Réjane Rua, , Douglas P. Dyer

This study shows CXCL4 enters the brain via GAG-binding to BBB proteoglycans and promotes neurogenesis through GAG-mediated oligomerization.

bioRxiv · Apr 23, 2025 · PreprintNeuroscience