Author

Marjolein Kikkert

Leiden University Medical CenterORCID 0000-0002-5779-7386Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Microbiology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:proteomics· 1

Frequent Co-Authors

Annemarthe G. van der VeeniD· 2 shared Adán Pinto-FernándeziD· 1 shared Andrew BowieiD· 1 shared Arnoud H. de RuiD· 1 shared Ayşegül SapmaziD· 1 shared Bart J.M. GrijmansiD· 1 shared Benedikt Mathias KessleriD· 1 shared Clarisse Salgado‐BenvindoiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

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2 shared papersBiochemistry

Annemarthe G. van der VeenORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

USP24 is an ISG15 cross-reactive deubiquitinasethat mediates IFN-I production by de-ISGylatingthe RNA helicase MOV10

Rishov Mukhopadhyay, Simeon D. Draganov, Timo Oosenbrug, Jimmy J. L. L. Akkermans, Marjolein Kikkert, Klaus‐Peter Knobeloch, Günter Fritz, M Ángeles Guzmán, Sonia Zúñiga, Robbert. Q. Kim, Annemarthe G. van der Veen, Benedikt Mathias Kessler, Adán Pinto-Fernández, Paul P. Geurink, Ayşegül Sapmaz

This study identifies USP24 as a novel ISG15 cross-reactive deubiquitinase that de-ISGylates MOV10 to negatively regulate IFN-I production.

Nature Communications · Jun 19, 2026Peer-reviewedBiochemistry

Vault RNAs aid viral infection by facilitating nuclear export of hnRNP C and ELAVL1

Jorn E. Stok, Sander B. van der Kooij, Dennis Gravekamp, Laurens R. ter Haar, Jasper W. de Wolf, Clarisse Salgado‐Benvindo, Tessa Nelemans, Bart J.M. Grijmans, Rayman T.N. Tjokrodirijo, Arnoud H. de Ru, Peter A. van Veelen, Martijn J. van Hemert, Marjolein Kikkert, Annemarthe G. van der Veen

This study shows that vault RNAs enhance viral replication by facilitating the nuclear export of ELAVL1 and hnRNP C, which are required for efficient viral replication.

bioRxiv · Oct 7, 2024 · PreprintMolecular Biology

Human coronavirus 229E infection inactivates pyroptosis executioner gasdermin D but ultimately leads to lytic cell death partly mediated by gasdermin E

Xavier Martiáñez–Vendrell, Jonna Bloeme, Roy Hutchinson, Coralie Guy, Andrew Bowie, Marjolein Kikkert

This study shows HCoV-229E Mpro inactivates GSDMD to block pyroptosis but promotes lytic cell death, partially via GSDME and caspases-3/-8.

Viruses · Jun 1, 2024Peer-reviewedMicrobiology