Hugh Garavan

Reproducible Human Reward Imaging Phenotypes Exhibit Differential Sensitivity to Dopamine D2 Receptor Antagonism

The paper identifies two reproducible reward imaging phenotypes linked to dopamine D2 receptor function and shows differential responses to antipsychotic drugs.

Protracted Maturation of Proactive and Reactive Systems Predicts Cognitive Stability and Psychopathology : A longitudinal multi-cohort study

The paper uses longitudinal fMRI data to show that proactive and reactive control networks stabilize after mid-adolescence, predicting cognitive stability and psychopathology.

Trajectories of brain organisation transition from predicting externalising to internalising symptoms across adolescence

The paper uses longitudinal neuroimaging and behavioural data to show how brain-behaviour relationships shift from externalising to internalising symptoms across adolescence, identifying age 14 as a critical transition point.

Bullying Victimization and Brain Development: A Longitudinal Structural Magnetic Resonance Imaging Study from Adolescence to Early Adulthood

This study links bullying victimization to structural brain changes in adolescents and young adults, showing sex-specific effects on brain regions involved in emotion and motor function.

Along-Tract Microstructural Alterations Associated with Stimulant Misuse Localized using Diffusion MRI Tractometry

This study uses diffusion MRI tractometry to identify localized white matter microstructural changes associated with stimulant misuse, finding distinct patterns for amphetamine use compared to cocaine use.

Connectome-Based Predictive Modeling of Concurrent and Prospective Substance Use in Adolescence

This study predicts adolescent substance use facets using resting-state connectivity, finding improved prediction accuracy over time with different facets being predicted at baseline and follow-up.

Uncovering Multi-Omics Profiles of Population Heterogeneity: A Cluster-Based Bayesian Approach

MOCHA identifies latent population subgroups with distinct genetic effects from multi-omics data, revealing two neurodevelopmental clusters linked to adolescent inhibitory control.

Anatomical connectivity profile development constrains medial-lateral topography in the dorsal prefrontal cortex

This study identifies developmental differences between dorsomedial and dorsolateral prefrontal cortex using multimodal data and transcriptomics, revealing a medial-lateral topographic division.

Mapping the coupling between tract reachability and cortical geometry of the human brain

This study maps the coupling between cortical geometry and white matter tract connectivity, showing how these aspects jointly shape brain function.

Chronic pain is linked to a resting-state neural archetype that optimizes learning from punishments

The paper identifies a neural archetype associated with chronic pain susceptibility by analyzing resting-state networks in population and clinical samples.

Brain Diffusion Transformer for Personalized Neuroscience and Psychiatry

The paper introduces Brain-DiT, a deep generative model for analyzing task-fMRI data, identifying cognitive regions and subgroups linked to psychiatric conditions like depression and alcohol abuse.

Unintended bias in the pursuit of collinearity solutions in fMRI analysis

The paper identifies unintended bias from collinearity reduction strategies in fMRI analysis and introduces a contrast-based variance inflation factor to assess their impact.

Genetic-Dependent Brain Signatures of Resilience: Interactions among Childhood Abuse, Genetic Risks and Brain Function

The paper identifies a genetic-dependent brain signature of resilience linked to childhood abuse and depression risk in girls, showing its predictive value for emotional disorders in adolescence and early adulthood.

Regional patterns of human cortex development correlate with underlying neurobiology

The paper links regional human cortex development and aging to molecular and cellular brain organization patterns using neuroimaging and gene expression data.

Variation in moment-to-moment brain state engagement changes across development and contributes to individual differences in executive function

This study examines how variability in brain state engagement changes with age and its relationship to executive function in youth.

Adolescent maturation of cortical excitation-inhibition balance based on individualized biophysical network modeling

This study develops an individualized in vivo marker of excitation-inhibition balance in adolescents using biophysical network models and finds increased inhibition in association cortices during development.

A robust brain network for sustained attention from adolescence to adulthood that predicts later substance use

This study shows that a brain network for sustained attention at age 14 predicts increased cannabis and cigarette use by age 23 in a longitudinal cohort.

Leveraging the Adolescent Brain Cognitive Development Study to improve behavioral prediction from neuroimaging in smaller replication samples

The paper uses the ABCD Study to determine optimal replication sample sizes for reproducible brain-behavior associations using neuroimaging data.

Adolescent to young adult longitudinal development of subcortical volumes in two European sites with four waves

The paper examines sex differences in subcortical brain volume trajectories across adolescence using longitudinal data from two European sites.

Federated analysis in COINSTAC reveals functional network connectivity and spectral links to smoking and alcohol consumption in nearly 2,000 adolescent brains

This study uses federated analysis in COINSTAC to examine functional network connectivity in adolescent brains linked to smoking and alcohol consumption, finding hypoconnectivity and reduced synchronization.

The ABCD Stop Signal Data: Response to Bissett et al.

This paper responds to criticisms of the ABCD Stop task, arguing that the concerns have minimal impact on neuroimaging and performance data, and highlights adjustments made to the task and data releases.

Performance Scaling for Structural MRI Surface Parcellations: A Machine Learning Analysis in the ABCD Study

This study examines how different brain parcellations affect predictive performance in machine learning models using structural MRI data from children.

Adolescent Brain Cognitive Development (ABCD) Community MRI Collection and Utilities

A curated collection of processed ABCD neuroimaging derivatives plus utilities for access, sharing and analysis, letting researchers exchange derivatives they cannot share through the central archive.

Meaningful Effects in the Adolescent Brain Cognitive Development Study

The paper describes the design and aims of the ABCD Study, discussing challenges in estimating meaningful associations and recommending best practices for research using its data.

The bidirectional causal effects of brain morphology across the life course and risk of Alzheimers disease: A cross-cohort comparison and Mendelian randomization meta-analysis

This study uses Mendelian randomization to examine bidirectional causal effects between brain morphology and Alzheimer's disease risk across different life stages.

Genetic variation in CSMD1 affects amygdala connectivity and prosocial behavior

This study identifies a genetic variant in CSMD1 associated with amygdala connectivity and prosocial behavior through a GWAS of brain networks in adolescents.

Towards Reproducible Brain-Wide Association Studies

Brain-behaviour correlations in ABCD are tiny (median |r|=0.01), so samples of typical size (N=25) give inflated, irreproducible results; estimates only stabilise around N⪆2,000.

Cognitive and brain development is independently influenced by socioeconomic status and polygenic scores for educational attainment.

This study examines the independent effects of socioeconomic status and genetic factors on brain development and cognition in adolescents, finding distinct associations with cortical surface area and working memory.

Neurobehavioural characterisation and stratification of reinforcement-related behaviour

The paper characterises and stratifies reinforcement-related behaviours by analysing neural activation patterns in adolescents using a statistical framework.

Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group

The paper reports epigenome-wide meta-analyses of blood DNA methylation with subcortical brain volumes, identifying significant associations with hippocampal volume and potential biological mechanisms.