Leonardo E. Valdivia

A novel pipeline for the validation of manganese chelators for the treatment of manganese overload

This paper develops a pipeline to identify and evaluate novel manganese chelators using zebrafish and mouse models, finding that H3PyC3A and Me3PyC3A show improved manganese mobilization and reduced accumulation.

Genetically interacting mutations and mechanical stress affect the stochasticity of developmental eye defects in yap1 mutants

The paper investigates stochastic developmental eye defects in zebrafish yap1 mutants, showing genetic and mechanical factors influence penetrance of retinal coloboma.

Insights into the FOXE3 Transcriptional Network and Disease Mechanisms from the Investigation of a Regulatory Variant Driving Complex Microphthalmia

The paper identifies a regulatory variant driving microphthalmia by analyzing its effects in mouse models and linking it to FOXE3 expression and ocular development.

A structural atlas of the developing zebrafish telencephalon based on spatially-restricted transgene expression

The paper maps the development of cell populations in the zebrafish telencephalon during eversion using transgene expression and creates a structural atlas.

Loss of slc39a14 causes simultaneous manganese deficiency and hypersensitivity in zebrafish

The paper identifies manganese deficiency and neurotoxicity in zebrafish slc39a14 mutants through transcriptome analysis, revealing key molecular pathways involved in manganese homeostasis disruption.

Abrogation of Stem Loop Binding Protein (Slbp) function leads to a failure of cells to transition from proliferation to differentiation, retinal coloboma and midline axon guidance deficits.

This study identifies Slbp as essential for cell cycle exit and neuronal differentiation in zebrafish, leading to retinal and brain defects.