This study shows that IFN-gamma signaling in cardiomyocytes causes metabolic changes in the heart, including increased glucose uptake and reduced oxidative phosphorylation, which resemble changes in aging and heart failure.

bioRxiv · Aug 31, 2025 · PreprintImmunology

Exploring global and specific pathogenic mechanisms in Chronic Chagas Cardiomyopathy through multi-omics integration

Pauline Brochet, Jorge Elias Kalil, Vincent Procaccio, Edécio Cunha‐Neto, Lionel Spinelli, Christophe Chevillard

This study identifies two distinct pathogenic pathways in Chronic Chagas Cardiomyopathy through multi-omics integration, involving IRF4 and TLR signaling, with B cell-related genes and shared B cell receptor features.

medRxiv · Oct 23, 2023 · PreprintGenetic & Genomic Medicine

Immunogenetics of resistance to SARS-CoV-2 infection in discordant couples

Erick C. Castelli, Mateus Vidigal de Castro, Michel Satya Naslavsky, Marília O. Scliar, Nayane dos Santos Brito Silva, Heloisa S. Andrade, Andréia S. Souza, Raphaela Neto Pereira, Camila Ferreira Bannwart Castro, Celso Teixeira Mendes‐Junior, Diogo Meyer, Kelly Nunes, Larissa R. B. Matos, Moníze V. R. Silva, Jaqueline Yu Ting Wang, , Mayana Zatz

The paper identifies genetic variants associated with resistance to SARS-CoV-2 infection by analyzing discordant Brazilian couples.

Frontiers in Immunology · Sep 28, 2021Peer-reviewedGenetic & Genomic Medicine