Thomas P. Cappola

Shared additive- and variance-associated genetic architecture of cardiac structure and function

The paper identifies shared and distinct genetic architectures for cardiac structure and function using UK Biobank data, revealing common variants influencing multiple chambers and phenotypic variability.

Large-scale evaluation of proteomic and polygenic risk scores reveals complementary contributions to incident disease prediction

The paper evaluates proteomic and polygenic risk scores for disease prediction, finding proteomic scores outperform polygenic scores in most traits and show temporal responsiveness.

Connecting intermediate phenotypes to disease using multi-omics in heart failure

This study uses multi-omics data to connect MRI-derived cardiac measures with gene and protein changes in heart failure, identifying shared pathways and novel insights into disease mechanisms.

Epigenome-wide association study for dilated cardiomyopathy in left ventricular heart tissue identifies putative gene sets associated with cardiac development and early indicators of cardiac risk

This study identifies 194 epigenome-wide significant CpGs associated with dilated cardiomyopathy (DCM) and links them to cardiac gene expression and cardiovascular risk factors.

Genome-Wide Fetalization of Enhancer Architecture in Heart Disease

The paper identifies widespread epigenomic changes in idiopathic dilated cardiomyopathy, showing a shift toward fetal-like enhancer states and providing a data resource for further study.

Genome wide association analysis in dilated cardiomyopathy reveals two new key players in systolic heart failure on chromosome 3p25.1 and 22q11.23

This study performs a large GWAS on dilated cardiomyopathy, identifying two new loci and confirming two existing ones, with potential therapeutic implications.

The genetic makeup of the electrocardiogram

This paper identifies novel genetic loci for cardiac disorders by analyzing the morphological effects of genetic variants across the entire cardiac cycle represented by the ECG.

Disease and phenotype relevant genetic variants identified from histone acetylomes in human hearts

The paper identifies genetic variants associated with heart failure by analyzing histone acetylation QTLs in human heart tissue.

Pathologic gene network rewiring implicates PPP1R3A as a central cardioprotective factor in pressure overload heart failure

The paper identifies PPP1R3A as a central cardioprotective factor in pressure overload heart failure by analyzing gene network rewiring in human hearts.