Shuji Ogino

Genetic architectures of proximal and distal colorectal cancer are partly distinct

This study identifies 13 new genetic loci specific to proximal or distal colorectal cancer subtypes, revealing partly distinct genetic architectures for these tumor locations.

Genome Scale Epigenetic Profiling Reveals Five Distinct Subtypes of Colorectal Cancer

The paper identifies five distinct subtypes of colorectal cancer using DNA methylation profiling and links them to specific mutations and gene body methylation patterns.

Gene regulatory network analysis identifies sex-linked differences in colon cancer drug metabolism processes

The paper identifies sex-linked differences in colon cancer drug metabolism via gene regulatory network analysis, showing improved survival in females with higher pathway targeting.

Inherited DNA Repair Defects in Colorectal Cancer

The paper identifies ATM and PALB2 as CRC risk genes through germline mutation analysis and highlights homologous recombination deficiency in CRC tumors.