Author

Peder Madsen

Aarhus UniversityORCID 0000-0002-8845-4802Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Mathias Kaas OllendorffiD· 3 shared Simon GlerupiD· 3 shared Joachim VilstrupiD· 2 shared Amanda Simonsen· 1 shared Anders DalbyiD· 1 shared Anders Dupont BørglumiD· 1 shared Anders EtzerodtiD· 1 shared Anna Quattropani· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersNeuroscience

Mathias Kaas OllendorffORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Reshaping the progranulin/sortilin interaction for targeted degradation of extracellular proteins

Camilla Gustafsen, Joachim Vilstrup, Marianne Kristensen, Ditte Køster, Jonas Lende, Casper Larsen, Amanda Simonsen, Astrid Damgaard Graversen, Ditte Olsen, Lone Tjener Pallesen, Christian Bjerggaard Vægter, Jean‐Claude Kresse, Michael Schou, Kathrin Weyer, Anders Etzerodt, , Simon Glerup

This paper develops SORTACs, small molecules that degrade extracellular proteins by hijacking the sortilin/progranulin interaction, showing nanomolar potency against TNFα.

Cell chemical biology · Mar 27, 2026Peer-reviewedBiochemistry

Rare missense variants of the leukocyte common antigen related receptor (LAR) display reduced activity in transcellular adhesion and synapse formation

Mathias Kaas Ollendorff, Nicolas Chofflet, Deniz Bicer, Sune Skeldal, Jinjie Duan, Benjamin Feller, Joachim Vilstrup, Rosa Groth, Suganya Sivagurunathan, Hesam Dashti, Jan Skov Pedersen, Thomas Mears Werge, Anders Dupont Børglum, Beth A. Cimini, Thouis R. Jones, , Simon Glerup

The paper identifies rare missense variants in LAR that destabilize the extracellular domain, disrupt LAR:NGL-3 interactions, and impair synaptic adhesion and synaptogenesis.

bioRxiv · Feb 16, 2025 · PreprintNeuroscience

A triple serine motif in the intracellular domains of sortilin-related receptors SorCS1-3 regulates neurotrophic activity

Anders Dalby, Mathias Kaas Ollendorff, Lars Meinertz Byg, Signe Bundgaard Christiansen, Simon Boggild, Per Qvist, Jens Randel Nyengaard, Peder Madsen, Simon Mølgaard, Simon Glerup

This study identifies a triple serine motif in SorCS1-3 intracellular domains that regulates neurotrophic signaling through phosphorylation, leading to CREB activation and BDNF pathway modulation.

bioRxiv · Oct 3, 2024 · PreprintNeuroscience