Rhea J. Longley

Functional analysis of novel microneme proteins from Plasmodium vivax blood stages identifies vaccine candidates

The paper identifies and characterizes two novel Plasmodium vivax merozoite proteins, PvMP45 and PvMP36, which bind reticulocyte receptors and are targets of protective antibodies, suggesting their potential as vaccine candidates.

PTRAMP, CSS and Ripr form a conserved complex required for merozoite invasion of Plasmodium species into erythrocytes

The paper identifies a conserved complex formed by PTRAMP, CSS, and Ripr in Plasmodium species that facilitates merozoite invasion of erythrocytes and shows its structural and functional conservation across species.

Cryo-EM structure of endogenous Plasmodium falciparum Pfs230 and Pfs48/45 fertilization complex

The paper determines the cryo-EM structure of the Plasmodium falciparum Pfs230-Pfs48/45 fertilization complex and identifies domains critical for function and vaccine design.

Navigating parasite antigen genetic diversity in the design of Plasmodium vivax serological exposure markers for malaria

This study evaluates how genetic diversity in Plasmodium vivax antigens affects serological markers for malaria exposure and finds that using multiple antigens can improve detection accuracy.

Development and validation of serological markers for detecting recent exposure to Plasmodium vivax infection

The paper identifies and validates a panel of 8 P. vivax proteins whose IgG antibody responses can detect recent exposure to P. vivax infections within the prior 9 months with 80% sensitivity and specificity.