Kang Zhang

IgG-Bridging-Seeded Synergistic Aggregation of SARS-CoV-2 Spikes Underlies Potent Neutralization by A Low-Affinity Antibody

This paper identifies a low-affinity SARS-CoV-2 antibody, P5-1C8, that neutralizes Omicron JN.1 through IgG-mediated spike aggregation rather than direct binding.

The Lipid Elongation Enzyme ELOVL2 is a molecular regulator of aging in the retina

This study shows that ELOVL2 regulates aging in the mouse retina by affecting fatty acid elongation and visual function, with potential therapeutic implications for age-related eye diseases.

Genome-wide co-localization of RNA-DNA interactions and fusion RNA pairs

The paper identifies a correlation between RNA-DNA interactions in normal cells and fusion RNA pairs in cancer, suggesting a mechanism for fusion transcript formation.

Big DNA as a tool to dissect an age-related macular degeneration-associated haplotype

The paper introduces a method to assemble synthetic haplotypes for functional analysis of AMD-associated variants, demonstrating its application to the 10q26 risk region.