Luca Massimino

RNA assignment and segmentation geometry in Visium HD profiles of fibrostenotic Crohn's disease

The paper evaluates segmentation methods for reconstructing cell-like profiles from spatial transcriptomics data but finds no reliable method under the given constraints.

Prostaglandin D2 synthase controls Schwann cells metabolism

This study shows that L-PGDS in Schwann cells maintains myelin integrity by altering metabolism and producing ketone bodies and acetate.

Balanced SET levels favor the correct enhancer repertoire during cell fate acquisition

The paper shows that SET levels influence enhancer usage during cell fate acquisition, leading to altered gene regulation and contributing to disease.

Whole brain delivery of an instability-prone Mecp2 transgene improves behavioral and molecular pathological defects in mouse models of Rett syndrome

AAV-PHP.eB-mediated delivery of an instability-prone Mecp2 transgene improves behavioral and molecular defects in Mecp2 mutant mice without severe toxicity.

In vivo CRISPRa decreases seizures and rescues cognitive deficits in a rodent model of epilepsy

This study uses CRISPRa to increase Kv1.1 expression in mouse hippocampal neurons, reducing seizures and cognitive deficits in a temporal lobe epilepsy model.

ZFP423 regulates early patterning and multiciliogenesis in the hindbrain choroid plexus

This study shows that ZFP423 is essential for hindbrain choroid plexus development, regulating early patterning and multiciliogenesis through gene expression and cell fate specification.