The paper identifies BACH2-driven tissue-resident memory programs in gut CD4+ T cells as a mechanism promoting HIV-1 persistence and suggests BACH2 as a therapeutic target.

Immunity · Aug 21, 2025Peer-reviewedImmunology

Multi-omic Characterization of HIV Effects at Single Cell Level across Human Brain Regions

Junchen Yang, Kriti Agrawal, Jay S. Stanley, Ruiqi Li, Nicholas Jacobs, Haowei Wang, Chang Fu Lu, Rihao Qu, Declan Clarke, Yuhang Chen, Yunzhe Jiang, Donglu Bai, Suchen Zheng, Howard S. Fox, Ya‐Chi Ho, , Serena Spudich

This study uses single-nucleus multiome sequencing to identify HIV-associated transcriptional and epigenetic changes in brain regions of individuals with HIV, revealing altered glial cell states and pro-inflammatory signaling.

bioRxiv · Feb 5, 2025 · PreprintBioinformatics

Multi-Omic Atlas reveals cytotoxic phenotype and ROS-linked metabolic quiescence as key features of CTL-resistant HIV-infected CD4+ T-cells

Alberto M. Herrera, Louise Leyre, Jared Weiler, Noemi Linden, Tan Thinh Huynh, Feng Wang, Colin C. Kovacs, Marina F. Caskey, Paul Zumbo, Maider Astorkia, Sandra N. Terry, Ya‐Chi Ho, Doron Betel, R. Brad Jones

bioRxiv · Dec 22, 2024 · PreprintImmunology

Restriction of SARS-CoV-2 Replication by Targeting Programmed -1 Ribosomal Frameshifting In Vitro

Yu Sun, Laura Abriola, Rachel O. Niederer, Savannah F. Steinhauser, Mia Madel Alfajaro, Valter Silva Monteiro, Craig B. Wilen, Ya‐Chi Ho, Wendy V. Gilbert, Yulia V. Surovtseva, Brett D. Lindenbach, Junjie U. Guo

This study identifies merafloxacin as a -1 PRF inhibitor that impedes SARS-CoV-2 replication in vitro.

Proceedings of the National Academy of Sciences · Jun 14, 2021Peer-reviewedMolecular Biology