Judith Houtman

Nup153 regulates neuronal responsiveness through HDAC1-mediated epigenetic modulation

This study identifies Nup153's role in repressing neuronal genes through HDAC1-mediated epigenetic regulation, influencing chromatin states and neuronal responsiveness.

Spermidine reduces neuroinflammation and soluble amyloid beta in an Alzheimer's disease mouse model

This study shows that spermidine reduces neuroinflammation and soluble amyloid beta in an Alzheimer's disease mouse model by targeting microglia and reducing inflammatory pathways.

The autophagy activator Spermidine ameliorates Alzheimer's disease pathology and neuroinflammation in mice

This study shows that Spermidine, an autophagy activator, reduces neuroinflammation and Aβ levels in AD-like mice by enhancing autophagy in microglia and astrocytes.