This study investigates the spatial-temporal evolution of extrachromosomal DNA (ecDNA) in glioblastoma, showing that EGFR ecDNA drives tumor evolution and identifies a potential therapeutic window for early intervention.

Cancer Discovery · Sep 8, 2025Peer-reviewedCancer Biology

Spatiotemporal dynamics of human microglia are linked with brain developmental processes across the lifespan

David A. Menassa, Tim A.O. Muntslag, María Martín‐Estebané, Liam Barry-Carroll, Mark A. Chapman, István Adorján, Teadora Tyler, Bethany Turnbull, Matthew J.J. Rose-Zerilli, James A. R. Nicoll, Željka Krsnik, Ivica Kostović, Diego Gómez‐Nicola

This study examines microglial dynamics across the human lifespan using postmortem tissues and RNAseq data, revealing novel developmental patterns linked to neurodevelopmental milestones.

Developmental Cell · Aug 16, 2022Peer-reviewedNeuroscience

Age dependent changes in synaptic NMDA receptor composition in adult human cortical neurons

Chrysia M. Pegasiou, Ardalan H Zolnourian, Diego Gómez‐Nicola, Katrin Deinhardt, James A. R. Nicoll, Aminul Islam Ahmed, Girish Vajramani, Paul Grundy, Matthijs B Verhoog, Huibert D. Mansvelder, Victor Hugh Perry, Diederik Olivier Bulters, Mariana Vargas‐Caballero

The paper shows an age-dependent decline in GluN2B-containing NMDA receptors in human cortical synapses, potentially contributing to age-related cognitive decline.

Cerebral Cortex · Feb 28, 2020Peer-reviewedNeuroscience