Emily M. Kibby

A minimal CRISPR polymerase produces decoy cyclic nucleotides to detect phage anti-defense proteins

The paper identifies a novel antiphage system, Panoptes, that uses a minimal CRISPR polymerase to produce cyclic nucleotides and detects phage anti-defense proteins through effector binding and nucleotide depletion.

Phage detection by a bacterial NLR-related protein is mediated by DnaJ

This study identifies DnaJ as essential for bNACHT25-mediated detection of RNA phages in E. coli, revealing a mechanism where phage coat protein activates the sensor without direct interaction.

A bacterial NLR-related protein senses distinct phage triggers through a single interface

This study identifies a bacterial NLR-related protein that detects phage infection through a conserved interface, triggering programmed cell death to limit viral spread.