Toni A. Nagy

RecBCD Prevents Bacterial Autoimmunity by Clearing Self-DNA Ends Produced During Replication Termination

The paper shows that RecBCD clears self-DNA ends during bacterial replication termination to prevent autoimmunity, similar to TREX1 and DBR1 in eukaryotes.

Identifying phage proteins that activate the bacterial innate immune system

The paper identifies phage proteins that activate bacterial innate immune systems by screening a plasmid library in diverse E. coli strains and analyzing plasmid depletion.

A minimal CRISPR polymerase produces decoy cyclic nucleotides to detect phage anti-defense proteins

The paper identifies a novel antiphage system, Panoptes, that uses a minimal CRISPR polymerase to produce cyclic nucleotides and detects phage anti-defense proteins through effector binding and nucleotide depletion.

Phage detection by a bacterial NLR-related protein is mediated by DnaJ

This study identifies DnaJ as essential for bNACHT25-mediated detection of RNA phages in E. coli, revealing a mechanism where phage coat protein activates the sensor without direct interaction.

A bacterial NLR-related protein senses distinct phage triggers through a single interface

This study identifies a bacterial NLR-related protein that detects phage infection through a conserved interface, triggering programmed cell death to limit viral spread.