Lucy He

Prolactin Receptor Long Isoform ΔS1 Expression is Reduced in the Dorsal Root Ganglia of Humans with Chronic Pain

The paper examines PRLR isoform expression in human dorsal root ganglia, finding higher PRLR-L (ΔS1) expression in females and reduced expression in females with chronic pain.

Chronic lower limb pain is not associated with a loss of inhibitory neurons in the human lumbar spinal dorsal horn

This study examines the anatomical changes in the human lumbar spinal dorsal horn in relation to chronic lower limb pain and finds no association with neuronal density or inhibitory neuron loss.

Meteorin resolves nociceptive hypersensitivity by reducing connexin-mediated coupling in satellite glial cells

This study shows meteorin reduces nociceptive hypersensitivity by decreasing connexin-mediated coupling in satellite glial cells, with long-lasting therapeutic effects in pain models.

Diroximel fumarate acts through Nrf2 to attenuate methylglyoxal-induced nociception in mice and decreases ISR activation in DRG neurons

This paper shows that diroximel fumarate (DRF) reduces MGO-induced pain hypersensitivity in mice by activating Nrf2 and decreasing ISR activation in DRG neurons.

Interleukin-6 induces nascent protein synthesis in human DRG nociceptors via MNK-eIF4E signaling

The paper shows IL-6 increases nascent protein synthesis in human DRG nociceptors through MNK1/2-eIF4E signaling, using human DRG explants and inhibitors.

Meteorin alleviates Paclitaxel-induced peripheral neuropathy in mice

This paper shows that recombinant mouse Meteorin reduces paclitaxel-induced neuropathy in mice by reversing glial reactivity and preventing nerve fiber loss.

A female-specific role for Calcitonin Gene-Related Peptide (CGRP) in rodent pain models

This study investigates the sex-specific role of CGRP in pain models, finding that CGRP promotes pain plasticity in female mice but has limited impact in males.