Author

Line Sinnathamby Reinert

Aarhus UniversityORCID 0000-0002-8317-0886Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 2 Neuroscience· 2

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Assay:scRNA-seq· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Søren R. PaludaniD· 4 shared Xin Lai· 3 shared Christian Bjerggaard VægteriD· 2 shared Ida Hyllen KlæstrupiD· 2 shared Kasper ThorseniD· 2 shared Lin LiniD· 2 shared Marina Romero‐RamosiD· 2 shared Xiangning DingiD· 2 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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4 shared papersImmunology

Søren R. PaludanORCID

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4 papers

Recent·Most cited

Distinct roles for DNA- and RNA-sensing immune pathways in control of genital HSV-2 infection and restriction of neuroinvasion

Xin Lai, Xiangning Ding, Ryo Narita, Alexander Schmitz, Mathias Franzén Boger, Gudrun Winther, Marie Beck Iversen, Giorgia Marino, S JENSEN, Kasper Thorsen, Ole Ahlgren, Christian Bjerggaard Vægter, Amanda Eskelund, Faezeh Darki, Thierry P. P. van den Bosch, , Søren R. Paludan

This study shows that DNA- and RNA-sensing immune pathways differently control genital HSV-2 infection and prevent neuroinvasion.

bioRxiv · Jul 7, 2026 · PreprintImmunology

Lack of functional STING modulates immunity but does not protect dopaminergic neurons in the alpha-synuclein preformed fibrils Parkinson's Disease mouse model

Ida Hyllen Klæstrup, Line Sinnathamby Reinert, Sara Almeida Ferreira, Johanne Lauritsen, Gitte U. Toft, Hjalte Gram, Poul Henning Jensen, Søren R. Paludan, Marina Romero‐Ramos

The paper investigates the role of STING in Parkinson's disease by comparing motor behavior and brain pathology in STING-deficient and wild-type mice exposed to alpha-synuclein fibrils.

npj Parkinson s Disease · Dec 11, 2025Peer-reviewedNeuroscience

Temporally resolved single-cell RNA sequencing reveals protective and pathological responses during herpes simplex virus 1 CNS infection

Xiangning Ding, Xin Lai, Ida Hyllen Klæstrup, Sara R. N. Jensen, Morten Milek Nielsen, Kasper Thorsen, Marina Romero‐Ramos, Yonglun Luo, Lin Lin, Line Sinnathamby Reinert, Søren R. Paludan

This study uses single-cell RNA sequencing to analyze the temporal cellular responses in the brain during HSV-1 infection, identifying distinct immune cell subpopulations and their roles in both protective and pathological processes.

Journal of Neuroinflammation · May 31, 2025Peer-reviewedImmunology

Mapping satellite glial cell heterogeneity reveals distinct spatial organization and signifies functional diversity in the dorsal root ganglion

Ole Andreas Ahlgreen, Mads W. Hansen, Jonas Baake, Thomas Engelbrecht Hybel, Rachele Rossi, Xin Lai, Ishwarya Sankaranarayanan, Johanne Pold, Lin Lin, Line Sinnathamby Reinert, Søren R. Paludan, Theodore John Price, Lone Tjener Pallesen, Christian Bjerggaard Vægter

The paper characterizes satellite glial cell (SGC) subtypes in mouse and human dorsal root ganglia using single-cell RNA sequencing and spatial techniques, revealing distinct functional roles and spatial organization.

bioRxiv · May 19, 2025 · PreprintNeuroscience