This study identifies the role of SPT2 in chromatin structure and function across Metazoa, showing its importance in germline development and chromatin accessibility.

bioRxiv · Feb 16, 2023 · PreprintMolecular Biology

Loss of the E3 ubiquitin ligases UBR-5 or HECD-1 restores Caenorhabditis elegans development in the absence of SWI/SNF function

Lisa Lampersberger, Francesca Conte, Subhanita Ghosh, Yutong Xiao, Jonathan L. Price, David Jordan, David Q. Matus, Peter Sarkies, Petra Beli, Eric Alexander Miska, Nicholas O. Burton

The paper identifies mutations in E3 ubiquitin ligases that restore development in SWI/SNF mutants in C. elegans, suggesting potential therapeutic targets for human developmental disorders.

Proceedings of the National Academy of Sciences · Jan 23, 2023Peer-reviewedDevelopmental Biology

The RNA Polymerase II core subunit RPB-9 directs transcriptional elongation at piRNA loci in Caenorhabditis elegans

Ahmet Can Berkyurek, Giulia Furlan, Lisa Lampersberger, Toni Beltran, Eva‐Maria Weick, Emily Nischwitz, Isabela Cunha Navarro, Fabian Braukmann, Alper Akay, Jonathan L. Price, Falk Butter, Peter Sarkies, Eric Alexander Miska

This study identifies RPB-9 as essential for piRNA-mediated silencing in C. elegans by promoting transcriptional elongation/termination at piRNA loci.

bioRxiv · May 1, 2020 · PreprintGenetics

The nascent RNA binding complex SFiNX licenses piRNA-guided heterochromatin formation

Júlia Batki, Jakob Schnabl, Juncheng Wang, Dominik Handler, Veselin I. Andreev, Christian E. Stieger, Maria Novatchkova, Lisa Lampersberger, Kotryna Kauneckaitė, Wei Xie, Karl Mechtler, Dinshaw J. Patel, Julius Brennecke

This study identifies SFiNX, a complex required for Piwi-mediated co-transcriptional silencing in Drosophila, revealing its role in piRNA-guided heterochromatin formation.

Nature Structural & Molecular Biology · Aug 1, 2019Peer-reviewedMolecular Biology