Promoter repression and 3D-restructuring resolves divergent developmental gene expression in TADs
Alessa R. Ringel, Quentin Szabo, Andrea M. Chiariello, Konrad Chudzik, Robert Schöpflin, Patricia Rothe, Alexandra L. Mattei, Tobias Zehnder, Dermot Harnett, Verena Laupert, Simona Bianco, Sara Hetzel, Mai H.Q. Phan, Magdalena Schindler, Daniel M. Ibrahim, , Michael I. Robson
The paper shows that divergent gene expression within TADs is resolved through TAD restructuring and DNA methylation, not enhancer-promoter compatibility or position.
bioRxiv · Oct 8, 2021 · PreprintGenetics