Author

Ling-jie He

Altos Labs

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

Adam S. FrostiD· 1 shared Advait SubramanianiD· 1 shared Aniliese DealiD· 1 shared Chen ZhangiD· 1 shared Christopher P. ArthuriD· 1 shared D. John LeeiD· 1 shared Da-li Tong· 1 shared Diego Acosta‐AlveariD· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperBiochemistry

Adam S. FrostORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Allosteric Disordering of eIF2B Regulates the Integrated Stress Response

Udit Dalwadi, Advait Subramanian, Aniliese Deal, Julia E. Conrad, Tamara Nadjsombati, Meera Venkatesh, Morgane Boone, Pascal F. Egea, Ling-jie He, Nimit Jain, D. John Lee, Yuwei Liu, Lucas Charles Reineke, Kazuki Saito, Nathaniel Talledge, , Adam S. Frost

This study identifies an allosteric mechanism in eIF2B that regulates the Integrated Stress Response by showing how eIF2-P binding inhibits eIF2B activity through latch-helix dislocation.

Nature Chemical Biology · Jun 29, 2026Peer-reviewedBiochemistry

Deleting Mecp2 from the entire cerebellum rather than its neuronal subtypes causes a delay in motor learning in mice

Nathan P. Achilly, Ling-jie He, Olivia A. Kim, Shogo Ohmae, Gregory J. Wojaczynski, Tao Lin, Roy V. Sillitoe, Javier F. Medina, Huda Yahya Zoghbi

This study shows that deleting Mecp2 from the entire cerebellum, but not from individual cell types, causes a delay in motor learning in mice.

eLife · Jan 26, 2021Peer-reviewedNeuroscience

The critical role of ASD-related gene CNTNAP3 in regulating synaptic development and social behavior in mice

Da-li Tong, Ruiguo Chen, Yulan Lu, Wei-ke Li, Yuefang Zhang, Jun-Kai Lin, Ling-jie He, Ting Dang, Shifang Shan, Xiaohong Xu, Yi Zhang, Chen Zhang, Yasong Du, Wenhao Zhou, Xiaoqun Wang, Zilong Qiu

This study identifies CNTNAP3 mutations in ASD cohorts and shows its role in synaptic development and social behavior in mice.

Neurobiology of Disease · May 28, 2019Peer-reviewedNeuroscience