Stefan Uderhardt

Quantifying distribution shifts in single-cell data with scXMatch

scXMatch quantifies distribution shifts between single-cell data from different conditions using a non-parametric graph-based test, showing robust performance across gene expression, chromatin accessibility, and morphology data.

MaSkel and napari-MaSkel: fast morphological skeleton feature extraction from segmentation masks

The paper introduces MaSkel and napari-MaSkel, tools for fast skeletonization and graph-based feature extraction from segmentation masks, using an optimized Lee94 thinning algorithm.

Glomerular Endothelial Cell-Derived Extracellular Vesicles Cross the Basement Membrane to Regulate Podocyte Function

This study shows glomerular endothelial cell-derived extracellular vesicles cross the basement membrane and regulate podocyte function through miR-mediated gene repression and protease activity.

Multiple clustered centrosomes in antigen-presenting cells foster T cell activation without MTOC polarization

This study shows that multiple clustered centrosomes in antigen-presenting cells enhance T cell activation by positioning near the cell center, unlike T cells where centrosomes polarize toward the immune synapse.

Antigen receptor competition in CAR-TCR cells changes cytotoxicity outcomes upon spatial antigen separation

The paper investigates how spatial separation of antigens affects cytotoxicity in CAR-TCR cells by analyzing clonotype dynamics and functional TCR contributions.

The synovial lining macrophage layer develops in the first weeks of life in a CSF1- and TGFβ- dependent but monocyte-independent process.

The paper identifies CSF1 and TGFβ as key signals for synovial lining macrophage development in mice, which occurs postnatally and is monocyte-independent.

High-accuracy prediction of 5-year progression-free melanoma survival using spatial proteomics and few-shot learning on primary tissue

This paper predicts 5-year progression-free survival in melanoma using spatial proteomics and few-shot learning, achieving over 90% accuracy.

Fetal liver macrophages contribute to the hematopoietic stem cell niche by controlling granulopoiesis

The paper identifies fetal liver macrophage subpopulations and shows their role in regulating granulopoiesis and the HSC niche during embryogenesis.