Joseph Schacherer

The paper investigates the phenotypic impact of a large non-recombining introgressed region in Lachancea kluyveri yeast, identifying loci affecting growth and gene expression.

The paper sequenced 53 Brettanomyces bruxellensis genomes to study genetic variation and its relationship with ploidy level and gene content.

The paper shows low-frequency genetic variants contribute significantly to phenotypic variation in a yeast population using a diallel cross experiment and GWAS.

This paper introduces a CRISPR/Cas9 method to generate precise, markerless translocations in yeast, enabling the study of chromosomal rearrangements' phenotypic effects independent of base substitutions.

This paper identifies Dog1 and Dog2 as 2DG detoxication enzymes in yeast, showing their regulation by signaling pathways and their role in 2DG resistance, with implications for human cancer therapy.

The paper uses Hi-C to assemble genomes from a mixed beer sample, identifying a novel yeast hybrid between Pichia membranifaciens and an undescribed yeast.

The paper presents a high-quality de novo genome assembly of Dekkera bruxellensis UMY321 using Nanopore and Illumina sequencing, providing insights into genomic variability within the species.

The paper examines meiotic recombination differences between Saccharomyces cerevisiae and Lachancea kluyveri, finding significant variations in recombination rates, crossover patterns, and hotspot conservation across evolutionary distances.

The paper evaluates nanopore-only genome assemblies of yeast isolates using MinION, showing improved contiguity and structural variant detection compared to Illumina-only assemblies.

The paper investigates Mendelian traits in yeast, finding that most are caused by common variants with stable inheritance, while a rare variant shows complex, context-dependent expression.