Julika Pitsch

This study uses single-cell transcriptomics to show that BRAFV600E-driven glioneuronal tumors have distinct immune profiles based on tumor grade, with SPP1 playing a key role in high-grade tumors.

The paper identifies early changes in hippocampal network activity that predict subsequent epilepsy in rats following perforant pathway stimulation.

This study identifies region-specific spreading depolarization as a key factor in post-ictal behavioral abnormalities in epilepsy using mouse and human data.

This study identifies SLK as critical for dendritic complexity and inhibitory synapse maintenance in neurons, with implications for human cortical malformations.

This study identifies how PI3K/mTOR signaling and Trp53 loss determine the heterogeneity and excitability of BRAFV600E-induced brain tumors in mice.

The paper investigates glutamate spread in the neuropil using optical reporters and finds that glutamate can activate AMPA and NMDA receptors at distances up to 2 micrometers from the release site.

This paper introduces a CRISPR-Cas9-engineered mouse model for GPI-anchor deficiency that mirrors human phenotypes, including cognitive impairments and epilepsy, and identifies synaptic transmission deficits.