Edgar R. Gomes

The actomyosin cortex controls t-tubule remodeling in muscle

This study identifies the actomyosin cortex, regulated by Arpc5, as critical for t-tubule remodeling in muscle, linking it to muscle function and disorders.

Myofibers drive postnatal myonuclear accretion through Arp2/3-dependent membrane protrusions

This study shows that myofibers use Arp2/3-dependent membrane protrusions to drive myoblast fusion and myonuclear accretion during postnatal muscle growth.

A 3D Tumor-on-a-chip Platform to Identify Drugs that Block Breast Cancer Cell Intravasation

This paper develops a 3D tumor-on-a-chip platform to study and test drugs that block breast cancer cell intravasation, showing that Dactolisib reduces intravasation without harming endothelial cells.

Microtubules coordinate mitochondria transport with myofibril morphogenesis during muscle development

This study shows microtubules coordinate mitochondria transport and myofibril formation during muscle development in Drosophila and mammals.

DypFISH: Dynamic Patterned FISH to Interrogate RNA and Protein Spatial and Temporal Subcellular Distribution

DypFISH quantitatively investigates spatial and temporal subcellular localization of RNA and protein using micropatterning and fluorescence microscopy, revealing reproducible patterns and dynamics.