Author

Johnathan L. Ballard

Texas A&M UniversityORCID 0000-0002-6973-6003Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:mouse· 1 Organism:non-human primate· 1 Approach:statistical model· 1

Frequent Co-Authors

Aidan R. O’BrieniD· 1 shared Allyson Berent· 1 shared Amy Gonzales· 1 shared Andrew HillhouseiD· 1 shared Andrew S. I. LoudoniD· 1 shared Andrew W. TraffordiD· 1 shared Ane Miren SalvadoriD· 1 shared Annalise SchlaferiD· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperGenetics

Aidan R. O’BrienORCID

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2 papers

Recent·Most cited

Development of an ASO therapy for Angelman syndrome by targeting an evolutionarily conserved region at the start of the UBE3A-AS transcript

Scott V. Dindot, Sarah Christian, William J. Murphy, Allyson Berent, Jennifer Panagoulias, Annalise Schlafer, Johnathan L. Ballard, Kamelia Radeva, Ruth Robinson, Luke S. Myers, Thomas Jepp, Hillary Shaheen, Paul Hillman, Kranti Konganti, Andrew Hillhouse, , Jill L. Silverman

This paper describes the development of an antisense oligonucleotide (ASO) therapy targeting the UBE3A-AS transcript to reactivate paternal UBE3A expression in Angelman syndrome models.

Science Translational Medicine · Mar 22, 2023Peer-reviewedGenetics

Re-Evaluating One-step Generation of Mice Carrying Conditional Alleles by CRISPR-Cas9-Mediated Genome Editing Technology

Channabasavaiah B. Gurumurthy, Aidan R. O’Brien, Rolen M. Quadros, John Adams, Pilar Alcaide, Shinya Ayabe, Johnathan L. Ballard, Surinder K. Batra, M.-C. Beauchamp, Kathleen A. Becker, Guillaume Bernas, David Brough, Francisco Javier Carrillo-Salinas, Wesley Chan, Hanying Chen, , Atsushi Yoshiki

The paper re-evaluates the efficiency of a CRISPR-Cas9 method for generating conditional knockout alleles in mice, finding very low success rates and high rates of undesired alleles.

Genome biology · Aug 25, 2019Peer-reviewedGenetics