The paper identifies LRRC57/RABIN as a presynaptic inhibitor of Rab GTPases in glutamatergic neurons, showing it regulates neurotransmitter release and prevents epileptiform activity.

bioRxiv · Sep 28, 2026 · PreprintNeuroscience

Chemokine-Dependent Natural Killer Cells Prevent Pulmonary Metastasis in a Newly Established Mouse Osteosarcoma Model

Jifeng Yang, Frédérique Zindy, Shaela Fields, Judith W. Hyle, Laura J. Janke, Qianqian Li, Beisi Xu, Qiong Zhang, Gang Wu, Ti‐Cheng Chang, Monika Wierdl, Lillian M. Guenther, Linda M. Hendershot, Martine F. Roussel, Charles J. Sherr, Chunliang Li

This study identifies CCL2 as a chemokine that limits osteosarcoma metastasis via NK cell signaling in a mouse model.

bioRxiv · Jul 20, 2026 · PreprintCancer Biology

Carbohydrate adaptation drives liver-brain axis maturation

Hongmei Cui, Zheng Wu, Yuannyu Zhang, Hieu Vu, Hongli Chen, Xiaofei Gao, Yan J. Jin, Donghong Cai, Sarada Achyutuni, Phong Nguyen, Chunxiao Pan, Hui Cao, Camenzind G. Robinson, Jeffery D Steinberg, Laura J. Janke, , Min Ni

The paper shows that LACTB2 in the liver regulates mitochondrial maturation to coordinate carbohydrate metabolism with brain development in mice.

bioRxiv · Nov 5, 2025 · PreprintDevelopmental Biology

MOZ and HBO1 Histone Acetyltransferase Complexes Are Molecular Dependencies and Therapeutic Targets in NUP98-Rearranged Acute Myeloid Leukemia

Nicole Lynn Michmerhuizen, Emily Heikamp, Ilaria Iacobucci, Masayuki Umeda, Bright Arthur, Vibhor Mishra, Chun Shik Park, Danika Di Giacomo, Ryan Hiltenbrand, Qingsong Gao, Sandi Radko-Juettner, Josi Lott, Cynthia Martucci, Varsha Subramanyam, Charlie Hatton, , Charles Grenfell Mullighan

This study identifies MOZ and HBO1 as molecular dependencies in NUP98-rearranged AML, showing their inhibition reduces leukemic burden and synergizes with Menin inhibitors.

Cancer Discovery · Jun 19, 2025Peer-reviewedCancer Biology