Sha Liu

This study shows that sleep deprivation in Drosophila impairs pattern separation by disrupting sparse coding in the mushroom body through SK channel-mediated changes in inhibitory neurons.

The paper shows that presynaptic release probability, not synaptic strength, decreases with sleep loss and affects sleep need across species.

This study shows that a constitutively active form of Unc13A reduces sleep rebound after deprivation, suggesting a role for SNARE complex dynamics in sleep homeostasis.

The paper develops astro-TRACT, a genetic tool to specifically target astrocytes in Drosophila neuronal circuits, revealing their morphology and synaptic connections.

The paper introduces iDOC, a platform for single-fly olfactory conditioning and memory assessment, showing spaced training promotes sleep while massed training induces anesthesia-resistant memory.

The paper identifies three molecular subgroups of parkinsonism in Drosophila using behavioral screening and machine learning, each linked to distinct cellular pathways.

The paper shows that astroglial calcium signaling in Drosophila increases with sleep need and is required for homeostatic sleep rebound, identifying TyrRII as a key receptor involved in this process.

This study creates a single-cell transcriptome catalogue of the Drosophila brain across its lifespan, revealing regulatory erosion and identifying novel neuronal states linked to ageing.

This study shows that ING1 regulates activity-induced gene expression in cortical neurons by interacting with other epigenetic factors and affecting synaptic plasticity-related genes.