Samuel A. Manning

Hippo pathway perturbation disrupts cell fate control in the Drosophila eye

The paper shows Hippo pathway disruption in Drosophila eye development leads to loss of cone and primary pigment cell fates due to increased EGFR pathway repressor activity.

Observing concurrent subcellular dynamics in large living tissues

This paper introduces Airy beam light sheet microscopy to image subcellular dynamics in large tissues with high spatial and temporal resolution across multiple organisms and biological processes.

The mechanosensitive protein Zyxin influences Hippo signalling and tissue growth via adherens junctions and basal spot junctions in Drosophila

This study shows Zyxin and Ajuba limit Hippo signaling and promote Drosophila tissue growth by regulating junctions and Warts kinase activity.

Hippo signalling regulates the nuclear behaviour and DNA dwell times of YAP and TEAD to control transcription

This study uses live microscopy to show that Hippo signalling regulates transcription by controlling the DNA dwell times of YAP and TEAD proteins.