Loren L. Looger

The paper identifies fold-switching proteins by analyzing inconsistencies in secondary structure predictions from amino acid sequences.

The paper identifies two types of motor cortex neurons with distinct roles in movement preparation and execution using single-cell profiling and axonal reconstructions.

The paper identifies shared and distinct transcriptomic cell types in two mouse neocortical regions using scRNA-seq, showing most excitatory types are region-specific while inhibitory types are shared.

The paper introduces variants of the glutamate sensor iGluSnFR with improved brightness, broader concentration detection, and different emission colors for enhanced in vivo imaging.

Structure-guided mutagenesis of GCaMP6 plus neuron-based screening yields a jGCaMP7 family, each variant tuned to a different regime: single spikes, neurites and neuropil, or population imaging.