Jeremy P. Hasseman

The paper shows that astrocyte activity drives brainwide changes in sensory, integrative, and motor computations during a passive state in zebrafish.

The paper develops two variants of a glutamate indicator with enhanced sensitivity and tailored deactivation rates for studying synaptic transmission in vivo.

This study evaluates RubyACRs as red-shifted optogenetic inhibitors in Drosophila, showing they effectively hyperpolarize neurons and induce circuit-specific behavioral changes.

This paper introduces two new far-red fluorescent GECIs, FR-GECO1a and FR-GECO1c, characterized for their Ca2+ sensitivity and performance in neuronal imaging.

The paper improves a GABA sensor, iGABASnFR2, with higher sensitivity and faster kinetics, enabling better in vivo imaging of GABAergic transmission.

The paper uses fluorescent sensors to study glutamate and GABA dynamics during interictal spikes and seizures in a rodent model, revealing a progressive failure of inhibitory restraint leading to seizures.

This paper develops improved glutamate indicators with faster activation kinetics and better synaptic localization for imaging synaptic transmission in neurons.

The paper identifies a mutation that enhances the sensitivity of a fluorescent voltage indicator, improving its ability to detect both spiking and subthreshold voltage signals in multiple organisms.

The paper develops fast and sensitive GCaMP indicators for neural activity imaging, achieving ultra-fast kinetics and high sensitivity.

The paper shows that volume-transmitted GABA waves drive epileptiform rhythms in hippocampal networks by elevating tonic GABAA receptor conductance across multiple cells.

The paper describes engineering eFRET voltage indicators with positive-going fluorescence responses by modifying microbial rhodopsins.

Structure-guided mutagenesis of GCaMP6 plus neuron-based screening yields a jGCaMP7 family, each variant tuned to a different regime: single spikes, neurites and neuropil, or population imaging.