Author

Oscar Franzén

Icahn School of Medicine at Mount SinaiORCID 0000-0002-7573-0812Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Genetics· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:GWAS summary statistics· 2 Approach:statistical model· 2 Approach:benchmark study· 1 Research Focus:gene regulatory network inference· 1 Research Focus:GWAS / association mapping· 1 Approach:machine learning (classical)· 1 Organism:mouse· 1

Frequent Co-Authors

Johan BjörkegreniD· 3 shared Adnan KastratiiD· 1 shared Aldons Jake LusisiD· 1 shared Annette PetersiD· 1 shared Antonio Fabio Di Narzo· 1 shared Arno RuusaleppiD· 1 shared Barbara StilleriD· 1 shared Beibei Jiang· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersSystems Biology

Johan BjörkegrenORCID

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3 papers

Recent·Most cited

Shared and distinct pathways and networks genetically linked to coronary artery disease between human and mouse

Zeyneb Kurt, Jenny Yeuk‐Ki Cheng, Rio Barrere‐Cain, Caden N. McQuillen, Zara Saleem, Neil Hsu, Nuoya Jiang, Calvin Pan, Oscar Franzén, Simon Koplev, Susanna Sue-Ming Wang, Johan Björkegren, Aldons Jake Lusis, Montgomery Blencowe, Xia Yang

This study identifies shared and distinct genetic pathways between human and mouse in coronary artery disease using multi-omics data and GWAS, showing over 75% shared pathways.

eLife · Aug 10, 2023Peer-reviewedSystems Biology

EnsembleCNV: An ensemble machine learning algorithm to identify and genotype copy number variation using SNP array data

Zhongyang Zhang, Haoxiang M. Cheng, Xiumei Hong, Antonio Fabio Di Narzo, Oscar Franzén, Shouneng Peng, Arno Ruusalepp, Jason Ciril Kovacic, Johan Björkegren, Xiaobin Wang, Ke Hao

EnsembleCNV improves CNV detection and genotyping using SNP arrays, achieving high accuracy and sensitivity for downstream GWAS.

Nucleic Acids Research · Jan 26, 2019Peer-reviewedBioinformatics

Cis-epistasis at the LPA locus and risk of coronary artery disease

Lingyao Zeng, Nazanin Mirza‐Schreiber, Claudia Lamina, Stefan Coassin, Christopher P. Nelson, Oscar Franzén, Marcus Edi Kleber, Salome Rebecca Mack, Till F. M. Andlauer, Beibei Jiang, Barbara Stiller, Ling Li, Christina Willenborg, Matthias Munz, Thorsten Kessler, , Heribert Schunkert

The paper identifies cis-epistasis at the LPA locus involving two SNPs that interact to modulate coronary artery disease risk and related traits.

bioRxiv · Jan 23, 2019 · PreprintGenetics